INVITATION Dear colleagues, On behalf of the organizers I am pleased to invite you to participate in the Fourth International Meeting "Mechanisms in Local Immunity". The Fourth Meeting of the Alps Adria Society for Immunology of Reproduction will be held as a joint meeting. The meeting will have many exciting themes and, among others, will provide a comprehensive focus on basic aspects of cytotoxicity and apoptosis, mechanisms in local immunity, and local immunity in sexually transmitted diseases. The meeting brings together prominent researchers from basic science and clinical investigation. In addition, there are selected oral presentations of the most interesting submissions by participants, and poster / workshop sessions, to present best results and ideas of the current research. Traditionally, we have an excursion to one of the jewels of Adriatic coast. Welcome to Opatija! Daniel Rukavina